All 20 clubs are back in action this weekend, with most playing their fifth game of the season. League leaders Manchester City travel to unbeaten West Ham, while their neighbours Manchester United will look to rebound from their defeat at Arsenal as they welcome Brighton to Old Trafford.
Some teams have already suffered injury blows, not least Chelsea, who will be without summer signing Christopher Nkunku for an extended period of time. However, the international break has brought fresh concerns for a number of managers.
According to Premier Injuries, some 103 Premier League players could be absent through injury or suspension for the next round of fixtures. Here, Mirror Football sheds more light on who is in good shape and who has a fair amount to worry about.
Some of those named were forced to pull out of their respective international squads, such as Man Utd's new signing Sofyan Amrabat and Liverpool defender Trent Alexander-Arnold. Others, though, picked up issues while away with their countries.
Arsenal - 4
Mohamed Elneny (knee), Thomas Partey (groin/hip/pelvic), Jurrien Timber (knee) - ruled out
Arsenal are sweating on the fitness of Gabriel (
Image:
Xinhua/REX/Shutterstock)
Gabriel (thigh) - doubtful
Aston Villa - 6
Emi Buendia (knee), Diego Carlos (unknown), Tim Ireogbunam (unknown), Tyrone Mings (knee) - ruled out
Alex Moreno (thigh), Jacob Ramsey (ankle/foot) - doubtful
Bournemouth - 5
Ryan Fredericks (calf/shin/heel), Emiliano Marcondes (ankle/foot), Dango Ouattara (ankle/foot), Alex Scott (knee) - ruled out
Tyler Adams (thigh) - doubtful
Brentford - 3
Shandon Baptiste (shoulder), Josh Dasilva (thigh), Ivan Toney (suspension) - ruled out
Mikkel Damsgaard (groin/hip/pelvic) - doubtful
Brighton - 4Julio Enciso (knee), Jakub Moder (knee) - ruled out
Evan Ferguson (knee), Danny Welbeck (unknown) - doubtful
Burnley - 6
Darko Churlinov (unknown), Hjalmar Ekdal (knee), Michael Obafemi (hamstring) - ruled out
Jordan Beyer (thigh), Aaron Ramsey (concussion), Vitinho (knee) - doubtful
Chelsea - 10
Marcus Bettinelli (knee), Armando Broja (knee), Carney Chukwuemeka (knee), Wesley Fofana (knee), Romeo Lavia (ankle/foot), Christopher Nkunku (knee) - ruled out
Benoit Badiashile (thigh), Trevoh Chalobah (thigh), Reece James (thigh), Mykhaylo Mudryk (calf/shin/heel) - doubtful
Crystal Palace - 2
Matheus Franca (back), Michael Olise (hamstring) - ruled out
Everton - 9
Dele Alli (groin), Seamus Coleman (knee) - ruled out
Jarrad Branthwaite (groin/hip/pelvic), Dominic Calvert-Lewin (head/face), Lewis Dobbin (knock), Andre Gomes (calf/shin/heel), Jack Harrison (groin/hip/pelvic), Michael Keane (knock), James Tarkowski (head/face) - doubtful
Fulham - 4
Tom Cairney (knee), Alex Iwobi (thigh), Sasa Lukic (knee), Joao Palhinha (other) - doubtful
Liverpool - 4
Virgil van Dijk (suspended) - ruled out
Trent Alexander-Arnold pulled out of the England squad (
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Getty Images)
Trent Alexander Arnold (thigh), Ibrahima Konate (thigh), Thiago (groin/hip/pelvic) - doubtful
Luton - 5
Jordan Clark (ankle/foot), Dan Potts (ankle/foot) - ruled out
Alfie Doughty (calf/shin/heel), Tom Lockyer (thigh), Gabriel Osho (knee) - doubtful.
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