In a group where the Gunners are strong favourites to progress, Arsenal now find themselves in a position where they ideally need a positive result in Seville. A loss could leave them four points off top spot with just three games remaining if Lens beat PSV in Group B's other clash.
As a result it's crucial that Arteta gets his starting line up correct for the game. Here football.london takes a look at who the Spaniard may pick.
Goalkeeper - David Raya
LONDON, ENGLAND - OCTOBER 21: David Raya of Arsenal acknowledges the fans during the Premier League match between Chelsea FC and Arsenal FC at Stamford Bridge on October 21, 2023 in London, England.
You could argue Mikel Arteta has made a rod for his own back by essentially anointing David Raya as his No.1. The Champions League does offer him a chance to change that. But it's unlikely that the Spaniard will bring back Aaron Ramsdale just yet. 1 of 11
Right-back - Ben White
Ben White has played every minute of Arsenal's Premier League campaign this season
As he edges closer to a new contract, Ben White is having a quietly spectacular season. It's no coincidence they lost the one game he didn't start. Expect him to continue against Sevilla. (Image: Stuart MacFarlane/Arsenal FC via Getty Images) 2 of 11
Centre-back - William Saliba
Mykhaylo Mudryk of Chelsea jumps for the ball with William Saliba of Arsenal leading to a possible handball incident for Saliba during the Premier League match between Chelsea FC and Arsenal FC at Stamford Bridge on October 21, 2023 in London, England.
Saliba was brutally unlucky to concede a penalty against Chelsea. He'll want to make amends for that out in Spain (Image: Photo by Michael Regan/Getty Images) 3 of 11
Centre-back - Gabriel
LENS, FRANCE - OCTOBER 3: Gabriel dos Santos Magalhaes of Arsenal during the UEFA Champions League match between RC Lens and Arsenal FC at Stade Bollaert-Delelis on October 3, 2023 in Lens, France. (Photo by Jean Catuffe/Getty Images)
Gabriel was not at his most solid on Saturday, but it maybe speaks to the high standards that he's set himself that he still played pretty well. He'll want to continue that against
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