The Gunners lead Group B with six points from three matches, a point better than Lens and four better than both Sevilla and PSV Eindhoven.
But the Gunners are also winless in back-to-back outings and would love to apply a UCL salve. Arsenal could even seal a place in the knockout rounds if they win and see Lens defeat PSV Eindhoven.
The same sides met two weeks ago, when Gabriel Martinelli and Gabriel Jesus scored in a 2-1 Arsenal win at the Ramon Sanchez Pizjuan Stadium.
How to watch Arsenal vs Sevilla live, stream link, start time
Kick off: 3pm ET, Wednesday (November 8)
How to watch: Paramount+ and TUDN USA
Focus on Arsenal, team news
Arsenal’s lost back-to-back games across all competitions, falling 3-1 at West Ham in the League Cup before a 1-0 setback at Newcastle in the Premier League.
Gabriel Jesus and Martin Odegaard are set to miss out, joining Emile Smith Rowe, Jurrien Timber, and Thomas Partey on the sidelines.
Focus on Sevilla, team news
Three-straight games without a loss, with draws at Cadiz and Celta Vigo sandwiched around a Copa del Rey win at lower league side Quintanar.
Sevilla has been dinged up at the back, with Marcao and Sergio Ramos missing time and both Marcos Acuna and Orjan Nyland joining them on the injury report.
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