With the group stage firmly in the rear-view mirror, it is time to continue the long march towards Wembley and it all begins tonight with Manchester City in Denmark to face Copenhagen and RB Leipzig hosting Real Madrid.
On Wednesday, it is the turn of Bayern Munich, who travel to Lazio, and Paris Saint-Germain as they welcome Real Sociedad to the French capital.
The eight ties are split over a fortnight of action with Arsenal waiting until Wednesday, February 21 to begin their tie with Porto.
That week also sees Inter Milan host Atletico Madrid, PSV face Borussia Dortmund and, in arguably the tie of the round, Italian champions Napoli meet Barcelona.
The second legs then take place over the weeks of March 4 and 11.
Champions League last-16 fixtures and results
How to watch Champions League on TV
TV channel: In the UK, the Champions League will be broadcast exclusively live on TNT Sports.
Live stream: Matches can be streamed live online for subscribers through the Discovery+ app and website.
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