Saka pulled up in the latter stages of the second half and appeared to be clutching his thigh.
After treatment, the winger was unable to play any further part in the game.
It was the latest blow to Arsenal, who were without captain Martin Odegaard after he suffered an injury on international duty with Norway.
Speaking after the match, manager Mikel Arteta admitted that he 'didn't know' the full extent of Saka's injury - leaving Arsenal fans with a nervous wait.
But a new report from the London Evening Standard appears to have shed new light on the situation.
It is claimed that Arsenal are now 'confident' that Saka's issue is not serious and expect him to make a full recovery this week.
It is understood that Saka was suffering from cramp, rather than a significant injury to his thigh, and could line up against Manchester City this weekend.
Before then, Arsenal will travel to reigning Europa League winners Atalanta for their first match of the new Champions League group stage format.
That match takes place on Thursday, with the City encounter kicking off three days later. It is unclear whether Saka will be fit to take on Atalanta.
Arsenal's Bukayo Saka limped off during the 1-0 win over Tottenham -
Getty
In his post-match interview at the Tottenham Hotspur Stadium, Arteta revealed that he barely slept due to the injuries suffered by Odegaard and Riccardo Calafiori in the build-up, as well as Declan Rice's suspension.
He told BBC Sport: "We had to adapt a little bit because of some of the players we lost.
"I prepared for Tottenham for five days. Then in one moment I lost one player, and in another I lost another. I didn't sleep much!
"There were no excuses, no crying. The players have thick skin. They love the game.
"Sometimes to win you have to do the ugly things and they love to do that. I loved it, because day after day the players are hungrier and hungrier."
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