The extent of Rice's injury is not yet known, with the midfielder having played the full 90 minutes of the Gunners' Premier League defeat by Newcastle United on Saturday.
But the news is a major blow after Arsenal’s recent midfield woes.
Rice has been a mainstay in midfield ever since joining the club for £105m from West Ham in July 2023, but Arsenal will have to cope without him at San Siro on Wednesday night.
Rice's absence represents another setback for Arsenal after a difficult couple of weeks for the club.
Martin Odegaard is back in the squad after returning to training on Tuesday morning
Martin Odegaard is back in the squad after returning to training on Tuesday morning
Odegaard returns to training as Arteta leadsArteta's side have failed to win any of their last three league games to fall seven points behind leaders Liverpool, and were rocked by the news on Monday that Edu has resigned from his position as sporting director.
On a more positive note is the return of captain Odegaard. The Norwegian trained with the first team today and has travelled to Italy.
Odegaard has been out of action for two months, having picked up an ankle injury while playing for Norway in the September international break.
Arsenal have taken seven points from their opening three Champions League matches.
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