Mikel Arteta has a few injury problems to mull over, with Gabriel Magalhaes seemingly a doubt after coming off against Liverpool. Martin Odegaard, meanwhile, will be hoping to return from his ankle injury at some point before the international break.
Express Sport takes a look at how Arsenal could line up at St James' Park...
Gabriel picked up an injury against Liverpool but could return this afternoon
Arsenal predicted XI vs Newcastle (4-3-3)
Goalkeeper - Raya
David Raya will take up his usual place between the sticks, with the Spaniard a certain starter unless he is injured. He has kept three clean sheets in nine Premier League games so far this season, conceding 10 goals along the way.
Raya will need to be at his best to keep the likes of Alexander Isak and Anthony Gordon at bay this afternoon.
Defence - White, Saliba, Gabriel, Timber
Gabriel could be in line to return for Arsenal in the heart of defence, with Arteta playing down any serious concerns before the midweek win over Preston. William Saliba will also be ready to play after serving his one-game suspension against Liverpool.
A late call is likely to be made on the fitness of Ben White, while Jurrien Timber will play on the left with Riccardo Calafiori unavailable. Takehiro Tomiyasu, who has a knee injury, will be unable to cover for White if the latter is deemed unfit.
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Midfield - Partey, Rice, Merino
Mikel Merino is likely to feature in midfield for Arsenal in place of Odegaard, who is still working his way back to full fitness. However, there is a chance that Leandro Trossard gets the nod instead of Merino if Arteta decides to take a more forward-thinking approach.
Declan Rice is almost certain to start in the middle of the park, with Thomas Partey set to return to his usual midfield role after deputising at right-back against Liverpool.
Attack - Saka, Martinelli, Havertz
Bukayo Saka will be hoping to get the better of Lewis Hall on the right-hand side, while Gabriel Martinelli could be picked to start ahead of Trossard on the left. Kai Havertz is expected to start in the middle following his goal against Preston on Wednesday.
He will need to prepare himself for arguably his toughest physical battle of the season against Dan Burn, who looks set to play at centre-back for Newcastle.
Predicted Arsenal XI vs Newcastle (4-3-3) - Raya; White, Saliba, Gabriel, Timber; Partey, Rice, Merino; Saka, Martinelli, Havertz.
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