Thomas Partey also returns to the starting 11 after coming on as a substitute against Nottingham Forest last week. Italian duo Riccardo Calafiori and Jorginho are the two players to make way.
That means Mikel Arteta continues with his front three of Leandro Trossard, Ethan Nwaneri and Mikel Merino - it's only a second European start for Nwaneri, who was an unused sub when we drew 1-1 here last season.
The hosts include Manchester United loanee Tyrell Malacia at left back, while captain Luuk de Jong leads the line up front - he scored against us in the Europa League back in 2022.
LINE-UPs
Arsenal: Raya, Timber, Lewis-Skelly, Saliba, Gabriel, Partey, Rice, Odegaard, Nwaneri, Trossard, Merino.
Subs: Neto, Setford, White, Kiwior, Zinchenko, Tierney, Calafiori, Jorginho, Sterling, Butler-Oyedeji, Kabia
PSV: Benitez, Ledezma, Malacia, Boscagli, Flamingo, Saibari, Schouten, Til, Perisic, Lang, de Jong.
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